Dynein



Dynein is a motor protein which walks along the microtubule toward its minus end, i.e. it is a minus-end directed motor. Dyneins are classified as cytoplasmic (DYNC) or axonemal. The Dyneins are composed of heavy, intermediate and light chains. For discussion of the DYNC inter mediate and light chains see: Dynein light and intermediate chain.

3D Structures of Dynein
Update June 2011

Dynein light chain
3dvt, 3bri - DmDYNC light chain - Drosophila melanogaster  3dvh - DmDYNC light chain (mutant)  1rhw - DmDYNC light chain - NMR 1ygt - DmDYNC light chain TcTex1 2e8j, 2b95, 1z09 - hDYNC light chain 2A – human – NMR 2hz5 - hDYNC light chain 2A 2zqq - hDYNC light chain 2 + peptide

1y4o - mDYNC light chain 2A – mouse 1re6 - mDYNC light chain 2 – NMR 1pwj, 1pwk, 1f3c - rDYNC light chain 2 – rat – NMR 1f95, 1f96 - rDYNC light chain + peptide – NMR 3dvp, 3brl, 3e2b - DmDYNC light chain + peptide 1yo3 – DYNC light chain 1 – Plasmodium falciparum 1xdx, 1m9l, 1ds9 - DYNC light chain TcTex1 – Chlamydomonas reinhardtii – NMR

Dynein intermediate chain
3l7h – DmDYNC intermediate chain light chain roadblock  3l9k - DmDYNC intermediate chain light chain roadblock + intermediate chain 3fm7, 3glw, 2pg1, 2p2t - DmDYNC intermediate chain + light chain

Dynein heavy chain
3qmz – DYNC heavy chain + glutathione-S-transferase – yeast 3err - mDYNC heavy chain microtubule-binding domain/Ser-tRNA synthetase

3ay1 - DYNC heavy chain – Dictyostelium discoideum